Pronunciation: gwye-FEN-ah-sin/sue-do-eh-FED-rin
Generic Name: Guaifenesin/Pseudoephedrine
Brand Name: Examples include Entex PSE and Zephrex LA
Guaifenesin/Pseudoephedrine Sustained-Release Tablets are used for:
Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.
Guaifenesin/Pseudoephedrine Sustained-Release Tablets are a decongestant and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.
Do NOT use Guaifenesin/Pseudoephedrine Sustained-Release Tablets if:
- you are allergic to any ingredient in Guaifenesin/Pseudoephedrine Sustained-Release Tablets
- you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)
- you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Guaifenesin/Pseudoephedrine Sustained-Release Tablets:
Some medical conditions may interact with Guaifenesin/Pseudoephedrine Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a fast, slow, or irregular heartbeat
- if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid
- if you have chronic cough
Some MEDICINES MAY INTERACT with Guaifenesin/Pseudoephedrine Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Guaifenesin/Pseudoephedrine Sustained-Release Tablets's side effects
- Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
- Bromocriptine because the risk of its side effects may be increased by Guaifenesin/Pseudoephedrine Sustained-Release Tablets
- Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Guaifenesin/Pseudoephedrine Sustained-Release Tablets
This may not be a complete list of all interactions that may occur. Ask your health care provider if Guaifenesin/Pseudoephedrine Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Guaifenesin/Pseudoephedrine Sustained-Release Tablets:
Use Guaifenesin/Pseudoephedrine Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Guaifenesin/Pseudoephedrine Sustained-Release Tablets by mouth with or without food.
- Take Guaifenesin/Pseudoephedrine Sustained-Release Tablets with a full glass of water (8 oz/240 mL) unless your doctor tells you otherwise.
- If you miss a dose of Guaifenesin/Pseudoephedrine Sustained-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Guaifenesin/Pseudoephedrine Sustained-Release Tablets.
Important safety information:
- Guaifenesin/Pseudoephedrine Sustained-Release Tablets may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Guaifenesin/Pseudoephedrine Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not take appetite suppressants while you are taking Guaifenesin/Pseudoephedrine Sustained-Release Tablets without checking with your doctor.
- Guaifenesin/Pseudoephedrine Sustained-Release Tablets has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
- Guaifenesin/Pseudoephedrine Sustained-Release Tablets may interfere with certain lab test results. Make sure that all of your doctors and lab personnel know that you are taking Guaifenesin/Pseudoephedrine Sustained-Release Tablets.
- Tell your doctor or dentist that you take Guaifenesin/Pseudoephedrine Sustained-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
- Use Guaifenesin/Pseudoephedrine Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
- Caution is advised when using Guaifenesin/Pseudoephedrine Sustained-Release Tablets in CHILDREN; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Guaifenesin/Pseudoephedrine Sustained-Release Tablets, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin/Pseudoephedrine Sustained-Release Tablets while pregnant. It is not known if Guaifenesin/Pseudoephedrine Sustained-Release Tablets are found in breast milk. Do not breast-feed while taking Guaifenesin/Pseudoephedrine Sustained-Release Tablets.
Possible side effects of Guaifenesin/Pseudoephedrine Sustained-Release Tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Guaifenesin/Pseudoephedrine side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.
Proper storage of Guaifenesin/Pseudoephedrine Sustained-Release Tablets:
Store Guaifenesin/Pseudoephedrine Sustained-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin/Pseudoephedrine Sustained-Release Tablets out of the reach of children and away from pets.
General information:
- If you have any questions about Guaifenesin/Pseudoephedrine Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
- Guaifenesin/Pseudoephedrine Sustained-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Guaifenesin/Pseudoephedrine Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Guaifenesin/Pseudoephedrine resources
- Guaifenesin/Pseudoephedrine Side Effects (in more detail)
- Guaifenesin/Pseudoephedrine Use in Pregnancy & Breastfeeding
- Drug Images
- Guaifenesin/Pseudoephedrine Drug Interactions
- Guaifenesin/Pseudoephedrine Support Group
- 58 Reviews for Guaifenesin/Pseudoephedrine - Add your own review/rating
Compare Guaifenesin/Pseudoephedrine with other medications
- Cough and Nasal Congestion
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